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It carries a Drug Affinity Complex a maleimidopropionyl-lysine group that covalently binds to the free thiol on cysteine-34 of circulating serum albumin after injection

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In this model, the KD from one JAK2 molecule bound to a Box1Box2 motif from one receptor is inhibited by interacting with the PKD from a different JAK2 molecule bound to the opposing receptor within the receptor homodimer

doi: 10.1016/j.tcb.2020.02.009 29 SalnikowK