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Dietary modifications can reduce both gastrointestinal side effects and associated urinary changes

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Consequently, elucidating the molecular mechanisms of epigenetic modifications during apoptosis in NAFLD/NASH-HCC is imperative for developing novel biomarkers and targeted therapeutic interventions [134]

The increase in the bile acid pool may then stimulate TGR5 bile acid receptors on the L cell [62, 67], causing an increase in GLP-1 secretion via mitochondrial oxidative phosphorylation and calcium influx [67]