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the present work is independent from Novo Nordisk A/S

Nature Metabolism

He called the four months after going off medication a roulette wheel of binges, diets, exercise regimens and mental and emotional battles with myself over will power, self-image and motivation. Olson said he gained back five pounds within two months, but was eventually able to lose it by imposing a strict regime: 12 hours of exercise a week and an extremely high-protein diet

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Ongoing research is evaluating whether future GLP-1 medications may reduce these effects

Because they can reduce caloric consumption, you might be missing out on necessary nutrients