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10.1124/pharmrev.123.000549 17 CaoY.LvJ.TanY.ChenR.JiangX.MengD.et al (2024)

Foundayos pivotal trial places its average weight loss at around 12%, with some patients losing up to 15%, while Mounjaro at the highest dose averages around 20%

Critics including clinicians, compounding pharmacists, and members of Congress, argued the move was an overreach that pushed patients toward unregulated grey-market sources, creating the very safety problem the FDA claimed to be solving

Similarly, the results of the validation cohort (FinnGen) likewise supported these findings (IVW: OR = 0.71, 95%CI: 0.520.96, P = 0.0246)

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basal insulin cut from 47 to 8-20 IU replacing basal-bolus (SURPASS-6)