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Short-term GHK-Cu use (weeks to few months) typically shows benefits gradually declining toward baseline over 2-4 months post-discontinuation as newly synthesized collagen undergoes normal degradation without replacement at treatment-stimulated rates

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Interestingly, in rats with a prolonged obstruction of blood vessels that underwent additional colon obstruction due to a ring around the colon (IC + OB rats), the evidence suggests that a bath administration of BPC 157 immediately (IC rats) or shortly thereafter (IC + RL rats) produced a beneficial effect and that the effect was even greater when BPC 157 was administered later (IC + OB rats)

we consider intervention in the next section