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Furthermore, treatment with Pluronic L-81, a surfactant that inhibits chylomicron formation, significantly attenuates the anorectic effects of intraduodenal lipids and attenuates both CCK release and celiac and cervical vagal afferent activation following lipid infusion 40,109,156,186

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This effect is not unique to retatrutide

GLP-1 receptor agonists use and incidence of glaucoma: a systematic review and Meta-analysis

They consist of identical mGIPR-Ab and differ only slightly in the conjugated GLP-1 moiety but demonstrate comparable in vitro potency at both receptors (Extended Data Fig