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10.1016/j.lfs.2021.119523 91 ShangJ.LiuF.ZhangB.DongK.LuM.JiangR.et al (2021)

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Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

At 3 months into treatment, repeat liver and kidney function testing confirms that medication metabolism is occurring without organ stress, and this baseline comparison helps distinguish treatment-related changes from underlying disease progression

This leads to increased bile acids in the intestinal lumen, which then trigger Takeda G-protein-coupled receptor 5 (TGR5) on L-cells, stimulating the production and release of GLP-1 (Thomas et al., 2009

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