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For example, because the plasma protein binding of valproate is concentration dependent, the free fraction increases from approximately 10% at 40 mcg/mL to 18.5% at 130 mcg/mL

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70-80% regain weight within a year

For patients with Lebers disease requiring vitamin B12, consider alternative therapy (e.g., hydroxocobalamin) for B12 supplementation

Diabetes Care 43 , 298305 (2020)

This medication is manufactured as a solution intended to be given by injection into a muscle or by slow infusion into a vein