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Furthermore, a recent 2024 study highlighted the critical role of CD8 T-cell dysfunction in both ME/CFS and Long COVID, noting that these immune cells produce markedly less necessary cytokines when exhausted by oxidative stress

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Thus, GSH and ATF4 levels in CML cells are the markers to indicate JMF4073 sensitivity and determine the selection of GSH blocker for the combination with JMF4073 in therapy