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Fumarate, one of the intermediates of the TCA cycle, is considered to be an oncometabolite that promotes cancer based on the human cases carrying heterozygous germline mutations in the fumarate hydratase ( FH ) gene

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In fact, the increase in insulin secretion induced by obesity, along with a decrease in insulin clearance, is sufficient to explain the increase in plasma insulin concentrations needed to maintain normoglycemia [27]

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