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No human trial has tested ipamorelin for GH optimization, body composition, or anti-aging endpoints

[3] [4] Administered as a once-weekly subcutaneous injection, Wegovy works by mimicking the action of the naturally occurring hormone GLP-1

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Patients should discuss with their healthcare provider how to handle missed doses for individualized advice

These inconsistencies underscore the necessity for additional high-powered methodologically rigorous trials to more definitively delineate the effect of GLP-1RA therapy on heart failure outcomes, thereby informing future revisions of clinical practice guidelines

The Phase 3 TRIUMPH-4 trial pushed these numbers even higher, with the 12 mg dose achieving 28.7% mean weight loss at 68 weeks