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Tres ensayos clnicos aleatorizados realizados en 594 pacientes sin DM2, demostraron una prdida de peso promedio de -3,2 kg (-4,3 a - 2,1 kg), mientras que en 18 estudios que incluyeron pacientes con DM2 se observ una prdida de peso promedio de 2,8 kg (-3,4 a -2,3 kg)

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