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GX reviewed the included articles and revised the manuscript

Growth Factor Modulation and Angiogenesis: A primary mechanism attributed to BPC-157 is its ability to promote angiogenesis, the formation of new blood vessels from pre-existing ones

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Common barriers include outdated formulary exclusions, obesity classifications as non-essential care, and Pharmacy Benefit Manager (PBM) utilization management strategies that are poorly suited for long-term, high-impact therapies