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Two investigators independently assessed study quality, compared results, and resolved any inconsistencies through discussion until reaching a consensus

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Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis

No evidence of carcinogenicity was seen in rats following oral administration of topiramate for 2 years at doses up to 120 mg/kg (approximately 4 to 10 times the MRHD of QSYMIA based on AUC estimates)

One store may see softening across traditional center-store categories while a nearby location picks up stronger movement in fresher, higher-protein, or smaller-portion products