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doi:10.1056/NEJMoa1501352

As purine/pyrimidine metabolites are required for transcriptional reprogramming 36 , some anabolic metabolisms for RNA and protein synthesis would also be supported by increases of purines and pyrimidines

29 It is also one of the basic processes (along with oxidative stress, mitochondrial dysfunction, and DNA damage) that hastens the aging process in all cells, tissues, and organs

Unbalanced Estrogen Metabolism in Ovarian Cancer. International Journal of Cancer