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Food and Drug Administration approved treatment for APAP induced liver injury ( in vitro and in vivo as possible alternative treatments for APAP induced liver injury (Xu et al., 2018), schisandra lignans (Zhu et al., 2019), polysaccharides (Wang et al., 2018), iridoids (Shao et al., 2017), flavonoids and quinones ( 2 Effects and mechanism of natural products in acetaminophen-induced hepatotoxicity A number of phytochemicals have been identified to have hepatoprotective activity, such as silymarin for the treatment of liver poisoning, chronic hepatitis and cirrhosis (Table 1)