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Necroptosis, one of the precisely controlled inflammatory cell death pathways, is a form of programmed necrosis activated by RIP1-receptor-interacting protein 3 (RIP3)-mixed lineage kinase domain-like pseudokinase (MLKL) complex, which eventually induced cell membrane permeabilization and cell necrosis (7)

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However, when their levels are too high and there are not enough antioxidants, free radicals can begin to damage DNA, proteins, and lipid tissues in cells

Briefly, each mouse was injected subcutaneously with 2 g -estradiol benzoate solution (Sigma, #E2758) on days 1, 4, and 7

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