A hydrogel microsphere with micelle microfluidic properties contains a ketone enol thiol-bridged nanoscale secondary structure, which downregulates TfR1 expression through metal chelation and increases the expression of CDGSH iron sulfur domain-containing protein 1 (CISD1), thereby restoring mitochondrial iron homeostasis and promoting cartilage repair (170)
We thus also analyzed the re-oxidation capacity after a reductive pulse, as the oxidation state in an unperturbed cell solely reflects the steady state
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IV protocols: 6002,000 mg per session, 12 times weekly
10.3748/wjg.v24.i48.5462 30 DuplancicB.StambolijaV.HoljevacJ.ZembaM.BalenovicI.DrmicD.et al (2014)