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Research published in PMC found that participants taking semaglutide lost an estimated 10% or more of their muscle mass during a 68-week treatment period, roughly equivalent to 20 years of age-related muscle loss

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Its defining trait is selectivity : at effective doses it does not meaningfully raise cortisol, ACTH or prolactin the key distinction from the older GHRP-2 and GHRP-6 peptides [3]