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Retatrutide is an investigational peptide compound that acts as a triple agonist, targeting three hormone receptors simultaneously: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Injection site rotation Rotate between at least three injection sites: the abdomen (2 or more inches from the navel), the front of the thigh, and the back of the upper arm

In research terms, these findings are valuable because they help define how tri-agonist receptor activation may influence interconnected physiological systems rather than a single metabolic endpoint [1][2][3]

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