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The guide on four weeks on semaglutide with no weight loss specifically addresses early non-response, while tirzepatide not working anymore addresses the scenario where effects diminish over time

[2] Regular monitoring is essential, including blood tests to assess disease activity (CRP, ESR), drug safety (liver and kidney function, blood counts), and periodic imaging to detect joint damage

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Wu G, Meininger CJ

and the change in the C-reactive protein (CRP) level