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Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90

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Stentz and colleagues note that high protein diet foods can be obtained at local grocery stores for $15/day providing an affordable meal plan for low income subjects.

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