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Strongest Current Evidence CagriSema REDEFINE 1 and REDEFINE 2 are completed phase 3 trials published in NEJM with over 4,600 participants

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However, evidence also suggests BCAAs may possess neuroprotective properties by supporting neuronal energy metabolism and protein synthesis to maintain neuronal function

In many cases, the metabolic benefits of these medications may outweigh theoretical concerns, particularly for patients with significant obesity or poorly controlled diabetes, which themselves carry health risks