None of the studies resulted in frank pancreatitis but two reported some increase in pancreatic inflammation at high levels of exenatide
If you have successfully used nighttime injection at lower doses, you can continue, but extend your buffer before lying down to a full 3 hours minimum
Step 3: Prepare the Medication Inspect the Vial: Ensure the medication is clear and free from particles
GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days
They are also the worst first choice for GLP-1 users
The most likely scenario is that the medication will not work as well, leading to increased hunger and stalled weight loss