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The pivotal STEP 1 trial ran for 68 weeks, and its data provide the clearest picture of when semaglutide's weight-loss effect peaks

In 44 patients with ALS, endogenous GLP-1 (and insulin and amylin) levels correlated with slower disease progression and inversely with the proinflammatory chemokine MCP-1, suggesting a potential protective link (169)

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10.1016/j.bcp.2017.08.021 136

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Q30: Can GLP-1's cause fatigue