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IL-15-mediated downregulation of FOXO1 and upregulation of CXCR6 increases the sensitivity of these cells to metabolic cues such as acetate and extracellular ATP, promoting MHC class I-independent killing of hepatocytes (142)

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When the production of these free radicals outpaces the bodys ability to neutralize them, the result is oxidative stress

3 Biotech 12:264

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(2011) 127:11801186.e1