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Contingent on promising early results, a major clinical trial (Phase 3) is conducted with hundreds to thousands of patients to confirm the treatments efficacy

The best evidence comes from small, randomized trials (with fewer than 20 people) that consistently have shown modest improvements in perceived sleep qualitymeaning, the participants reported that they slept better and were less tired the next day

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Research indicates that the severity of PD-related constipation helps diagnose the PD stage, with 67% sensitivity and 90% specificity (Hashish and Salama, 2023)

doi: 10.1074/jbc.M115.700534