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In older animals, both high-dose paraxanthine and caffeine (CAF HIGH) produced the most significant improvements, consistent with previous research showing age-related declines in learning and memory acquisition in water maze tests
Within eukaryotic cells, a-helical ACPs can induce mitochondrial infiltration and swelling, releasing cytochrome c (Cytc), ultimately leading to cancer cell apoptosis
While individual antioxidants have differing molecular structures, their shared mechanism of action in targeting oxidative stress-induced endothelial dysfunction provides a rationale for evaluating them as a therapeutic class [11]
This aging mechanism is closely related to various common diseases, including atherosclerosis, hypertension, chronic obstructive pulmonary disease, diabetes, and neurodegenerative disorders ( Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib ( Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs
doi: 10.1007/s10815-012-9855-2 27 ChenYYangSHZhengWZuRWRanSYWuHet al
