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Retatrutide starts at 2 mg and steps up to 4, 8, and 12 mg over roughly 16 weeks, at least on the Phase 2 schedule, since Phase 3 may shuffle that

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While the researchers did not find evidence that people who lost more body weight had a larger reduction in cardiovascular risk, they did find that larger decreases in waist circumference (a more sensitive marker of visceral fat) accounted for roughly a third of the reduction in cardiac risk in the semaglutide group, still leaving most of the benefit unexplained by changes in body composition