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Seo E, Kang H, Choi H, Choi W, Jun H

To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

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The gut is heavily innervated by the vagus nerve, which serves as the primary communication highway between the enteric nervous system and the central nervous system