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Eliud Sifonte, a diabetes and metabolism endocrinologist affiliated with NYU Langone Health, told Flow Space

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Prenatal treatment with a single dose of VPA, mainly on embryonic day (E) 12.5 in mice (44) and rats (94, 95) but as late as E17 in mice (96) reduced GAD expression in different brain regions that suggests a lower number of GABAergic neurons (9496), and reduced GABA concentrations and the number of GABA receptors (44)

Factors such as age, sex, baseline fitness level, genetic polymorphisms, and even vitamin D status may modulate the degree to which these growth factors are upregulated

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