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Participants in RCTs typically comprise relatively healthy individuals, excluding those with a history of medullary thyroid cancer or pancreatitis, and the duration of the RCTs is insufficient to induce cancer

Patients should refer to NICE TA875 and the Wegovy SmPC (available on the EMC) for full eligibility criteria

Body-composition change A 2025 substudy in The Lancet Diabetes & Endocrinology used imaging to separate fat mass from lean mass in participants with type 2 diabetes

Research in this area remains limited but emerging evidence provides some guidance

Effects of PEDs Learn more about the health and safety risks associated with prohibited substances and methods

Still, these approaches are in laboratory testing, not clinical practice