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Collectively, these pathway-specific actions highlight the therapeutic promise of natural compounds as multi-targeted agents in AD treatment

Vitamin E, 750 mg/kg intraperitoneally, given with 5-fluorouracil had a greater anti-tumor effect in mice bearing human colon cancer lines than either agent alone

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The dry and wet forms of beriberi involve peripheral neuropathy, whereas cerebral beriberi can lead to neuronal cell death and the clinical conditions of Wernicke's encephalopathy and Korsakoff's psychosis, especially in those who chronically abuse alcohol (22, 24)

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