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92 SahathevanS.SeC.NgS.KhorB.ChinnaK.GohB.et al (2018)

SGLT2 inhibitors might not cause EDKA by themselves but instead create a predisposition that can lead to the condition when certain triggering factors are present

Heat shock can result in oxidative stress as heat can trigger intensified respiration, leading to elevated intracellular oxidation levels 34,35

The TRANSCEND-T2D-1 trial adds a second pressure point: 16.8% body weight reduction in patients with type 2 diabetes, a population that consistently underperforms on weight-loss endpoints with existing agents

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