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Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector

NRF2 is tightly regulated at different levels by epigenetic modifications such as OS, inflammation, and different forms of stress [148], and has regulatory functions in mitochondrial biogenesis and cellular energy metabolism [149]

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Deroissart, J., Binder, C