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Glucagon receptor agonism: Increases energy expenditure and promotes fat oxidation, contributing to weight reduction

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These structural changes greatly increase the GLP-1 like peptide's half life (t 1/2 = 1 week) compared to endogenous GLP-1 (t 1/2 = 2 minutes)

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Furthermore, those who died during followup could have been misclassified, that is, as nonadherent

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