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(Samuel & Shulman, 2016) Visceral adipose tissue amplifies both pathways by releasing free fatty acids into the portal circulation and secreting pro-inflammatory adipokines, which is why visceral fat specifically not body weight as a global variable is the more precise metabolic target

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doi: 10.1007/s00125-005-0097-z 189 Love-OsborneKSheederJZeitlerP

The Reality Check: What We Don't Know Yet This is the section the hype machine skips

The real issue is pharmacodynamic overlap: both influence heart rate and blood pressure, so together they can raise the risk of hypotension, dizziness, or excessive bradycardia