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This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis

These mechanisms are crucial for maintaining maternal-fetal interface immune balance and preventing embryonic rejection ( + T cells, while stimulating IFN- and IL-2 secretion

In 2010, the first human trial using RNAi technology was conducted to evaluate the therapeutic effect of siRNA for targeting the M2 subunit of ribonucleotide reductase in patients with melanoma

These investigations continue expanding scientific understanding of metal-ion biology and peptide-mediated biochemical regulation without implying approved therapeutic applications

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