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This article provides evidence that targeting both HIF1 and HIF2 is necessary to prevent retinal neovascularization in patients with sickle cell retinopathy

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In human retinal pigment epithelium cells, bilberry anthocyanins have been demonstrated to modulate the oxidative stress-protective enzymes glutathione S-transferase-pi and heme oxygenase-1 (HO-1) [269]