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The driving mechanism is likely weight loss, given that obesity is the primary modifiable risk factor for OSA

Among these, keratinocytes exhibit the highest levels of VDR expression, particularly within the basal and spinous layers of the epidermis [47]

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This shifts the hypothalamus toward suppression of GHRH secretion, meaning your endogenous pulsatile GH release is already dampened before sermorelin even enters the picture

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.De Mesquita Y

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