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they observed that the mean enzymatic activities of xenobiotic metabolizing enzymes such as cytochrome P450 1A1 (CYP1A1), aromatase (CYP19A1), and glutathione-S-transferase (GST) were lower in three placental microsomes and subcellular membrane fractions

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

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The decrease in NADPH-oxidase activity in response to chronic PE can increase the availability of NADPH for glutathione reductase to renew GSH and TRx (SH)2 (Jenkins and Goldfarb, 1993