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The safety and value depend on each product and its manufacturer

Consequently, NSAIDs can increase the risk of gastric irritation, ulceration, and gastrointestinal bleeding, particularly with prolonged use, higher doses, or in vulnerable populations such as older adults or those with a history of peptic ulcer disease

While there have been shortages of GLP-1s, Lilly and Novo Nordisk have also built up production and distribution capacity, achieving economies of scale

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R is calculated as (ALT ULN ALP)/(ALP ULN ALT)