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Glucagon-like peptide-1: a potent regulator of food intake in humans

5 1 2025

For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

Development of a co-formulation of orally administered semaglutide with the absorption enhancer sodium N -(8-[2-hydroxybenzoyl]amino)caprylate (SNAC) has overcome the barrier of poor absorption and degradation in the stomach [11]