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Similar to their expression increases in the pediatric/adult stages compared to the fetal stage, the expression of claudins ( CLDN1 and CLDN2 ) and zonula occludens-1 ( ZO-1 ) in preterm intestinal organoids was increased by EV39 treatment (Fig

The result was largely driven by one large cohort, and neither study reported specific urinary malformation subtypes, limiting causal interpretation

Steroid-sparing treatments, including immunosuppressive agents and biologics such as hydroxychloroquine, can reduce dependence on corticosteroids and limit their associated damage (109)

This reduces injection volumes at higher doses but makes low doses (0.25mg = 5 units) very difficult to measure accurately

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