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The local-versus-systemic distinction is one more reason the strong transgenic findings cannot be assumed to predict what a circulating IGF-1 LR3 dose would do, and it further separates the natural, loading-responsive biology (closer to the MGF concept) from the pharmacology of an engineered systemic agonist

McKenna MJ, Zempel JA, Braun WH

For botanical compounds and nutrients, transdermal absorption is more variable and depends on molecular size, lipid solubility, and formulation technology

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