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Hence, we further discuss the clinical trials that explain the important role of these drugs in cancer treatment

As anthracyclines are ROS-generating drugs, one of the resistance mechanisms might be related to the ability of cancer cells to evade this insult

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Importantly, Ca 2+ - and ROS-dependent LMP has been reported to contribute to necroptosis via release of cathepsins, cathepsins-mediated mitochondrial dysfunction, and lysosome-dependent regulation of RIPK1 and RIPK3 post-translational modifications [141]