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Excess glucose drives mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress, which can disrupt intracellular trafficking and impair the delivery of OCTN2 to the plasma membrane [112]

In particular, vitamin D deficiency was identified to negatively regulate microRNA-196b- 5p (regulatory microRNA that helps maintain normal granulosa cell growth and survival) which negatively affected its target genes operating in granulosa cells

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