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These changes impair dynamic joint stabilization and contribute to further joint instability and pain, forming a deleterious feedback loop with intra-articular degeneration (Table 1) (Cruz Ayala et al., 2022

Keywords : radiation pneumonitis (RP), radiation induced lung injury (RILI), lipopolysaccharide (LPS)-induced pneumonitis, therapeutic targets, molecular pathways Radiation pneumonitis (RP) is a common side effect of radiotherapy, frequently arising after the irradiation of malignant tumors in the chest and breast, particularly in the treatment of lung cancer