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mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

Research has also shown that under serine-deficient conditions, pancreatic ductal adenocarcinoma (PDAC) cells maintain intracellular serine levels by upregulating PHGDH, adapting to the harsh microenvironment and promoting tumor progression ( de novo serine synthesis, and reduces the dependence of tumor cells on environmental serine ( 4.2.3 Bladder cancer Frequent FGFR3 mutations in bladder cancer constitute one of the core drivers of SSP activation

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They, therefore, suggested administering a second dose of PRP where necessary at about three months in the case of partial recovery as a boost dose [23]