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The discrepancy between demonstrated subcutaneous efficacy (or lack thereof) and marketed oral supplements creates a fundamental problem: commercially available AOD-9604 supplements likely deliver negligible systemic peptide due to oral bioavailability limitations

For a 200-pound person, it means 24 to 30 pounds

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Jansen J, Fedecostante M, Wilmer MJ et al (2016b) Bioengineered kidney tubules efficiently excrete uremic toxins

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